Association ofMetabolic Dysregulation With Volumetric BrainMagnetic Resonance Imaging and Cognitive Markers of Subclinical Brain Aging in Middle-Aged Adults The Framingham Offspring Study

نویسندگان

  • ZALDY S. TAN
  • JAYANDRA J. HIMALI
  • STEPHANIE DEBETTE
  • SUDHA SESHADRI
چکیده

OBJECTIVE—Diabetic and prediabtic states, including insulin resistance, fasting hyperglycemia, and hyperinsulinemia, are associated with metabolic dysregulation. These components have been individually linked to increased risks of cognitive decline and Alzheimer’s disease. We aimed to comprehensively relate all of the components of metabolic dysregulation to cognitive function and brain magnetic resonance imaging (MRI) in middle-aged adults.

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Association of Metabolic Dysregulation With Volumetric Brain Magnetic Resonance Imaging and Cognitive Markers of Subclinical Brain Aging in Middle-Aged Adults

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تاریخ انتشار 2011